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Immunohistochemical analysis of a panel of human melanoma cell lines showed that EGFR expression varied from approximately 11 to approximately 75%. A 4-day in vitro assay demonstrated that erlotinib had a dose-dependent inhibition of human melanoma cell proliferation. Erlotinib was more effective in inhibiting cell proliferation in tumor cells that expressed EGFR in an in vitro assay. The results of this study show that the EGFR pathway may play a role in the growth of human melanoma and that the EGFR pathway may represent a rational target for the development of new chemotherapeutic drugs in this disease.A in the first test, which is very good. I was hoping for something like 8 percent higher. I wasn’t very optimistic with that forecast, but it’s still a nice bump in most cases,” he said. 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